Abstract This session will highlight modern sampling approaches for fast high-resolution MR imaging. Single and multiple coil imaging will be considered, in the context of structural, dynamic, or flow applications. Organizer and chair : Prof. M. Lustig  |
Abstract Diffusion MRI (dMRI) is the unique Magnetic Resonance Imaging modality able to quantify in vivo and non invasively the average random thermal movement (diffusion) of water molecules in biological tissues such as brain white matter. Using the water diffusion as a probe, dMRI makes it possible to reconstruct white matter fiber pathways and segment major fiber bundles that reflect the structures in the brain which are not visible to other non-invasive imaging modalities. This modern imaging modality, of great interest to neuroscientists and clinicians, has opened a number of challenging problems.
A keynote talk by Denis Le Bihan, credited with developing, refining, and introducing into research and clinical practice the concept of diffusion MRI, will open this session. Denis will introduce this method, help us better understand water diffusion MRI and shed light on what we are looking at when measuring water molecule motion.
In the following 4 technical talks, given by internationally well known experts in computational diffusion MRI, emphasize will be on the presentation of extremely innovative methods recently developed to process and analyse diffusion weighted images with applications to questions of utmost scientific and clinical importance in brain imaging. The 4 talks will have a focus on these tasks, well known to be very challenging due to the complex underlying properties of the diffusion signal. These talks will include recent developments in complexe diffusion modelling from the processing of High Angular Resolution Diffusion Imaging (HARDI) data. HARDI overcomes the limits of
diffusion tensor imaging (DTI) and is able to recover complex fiber crossing configurations. These new methods open the possibility of inferring and recovering a more detailed geometric description of the anatomical connectivity between brain areas. Many recent HARDI reconstruction techniques have been introduced to reconstruct the ensemble average propagator (EAP) that captures the diffusion process of water molecules. In the 4 technical talks of this session, HARDI techniques that currently exist on single-shell and beyond will be presented and discussed with a particular focus on the use of Riemann Finsler geometry and dictionary learning based techniques that reconstruct the EAP and its angular part, the orientation distribution function (ODF). From the ODF, it will be shown how one can perform fiber tracking and reconstruct brain connectivity in healthy subjects and patients with brain tumors. In particular, a neurosurgical application will be illustrated. Finally, starting from the fundamentals and based on the fact that the MR signal can be sensitized to self-diffusion of water molecules whose motional history is influenced by the local micro-structure, the last talk will present the computational challenges and essential features of diffusion MR that makes it a powerful probe to characterize tissue micro-structure. Organizer and chair : Dr. R. Deriche  |